منابع مشابه
miRNAs halt cell cycle
608 Cells lacking miRNAs (bottom) do not differentiate into muscle (right). miRNAs halt cell cycle M uscle-specifi c miRNAs can induce differentiation at least in part by depleting DNA polymerase α mRNA, according to Kim et al. (page 677). Although other factors are also involved in the differentiation process, obliterating the DNA replication machinery is a novel means to bring the cell cycle ...
متن کاملRestarting the cell cycle when the checkpoint comes to a halt.
The DNA damage checkpoint coordinates a block in cell proliferation with the DNA repair process that follows when lesions are inflicted on the genome. However, we do not know exactly how cell division can recommence following a DNA damage-induced arrest. Recent work from our lab has identified Polo-like kinase-1 and Cdc25B as two essential components of the machinery that sets the cell division...
متن کاملS01-03 miRNAs couple cell cycle, cell fate and developmental timing in retinal histogenesis
Eukaryotes contain small regulatory RNAs that have been referred to as the dark matter of genetics. They are typically 21– 24 nucleotides long, associated with Argonaut or Piwi proteins. Some of these small RNAs guide the Argonaut/Piwi protein to a complementary RNA and they are negative regulators of gene expression acting at the level of messenger RNA turnover or translation. Others participa...
متن کاملCell cycle and apoptosis: A review
Cancer is characterized by abnormally excessive cell proliferation. Cell proliferation, the process by which a cell grows and divides to produce two daughter cells. Each of these daughter cells divides to produce two new cells, steps that are called cell cycle. Meanwhile, apoptosis is a highly regulated process of cell death, which is involved not only in the development of shape and morphogene...
متن کاملCirculating miRNAs: cell–cell communication function?
Nuclease resistant extracellular miRNAs have been found in all known biological fluids. The biological function of extracellular miRNAs remains questionable; however, strong evidence suggests that these miRNAs can be more than just byproducts of cellular activity. Some extracellular miRNA species might carry cell-cell signaling function during various physiological and pathological processes. I...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2006
ISSN: 1540-8140,0021-9525
DOI: 10.1083/jcb.1745iti1